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1 Faculdade de Quimica, CEATEC/PUC-Campinas, Rodovia Dom Pedro I, Km 136 - Parque
das Universidades - 13086-900, Campinas, SP, Brasil
2 IFGW/UNICAMP, Cidade Universitaria Zeferino Vaz, 13083-970, Campinas, SP, Brasil
| The observation of liposomes made up of phospholipides by atomic force microscopy has enabled direct visualization of their structure. Molecularly resolved force versus distance curves of the liposomes supported on silanized mica in water display the organization of hydrocarbon chains and the presence of distinct adsorbed structures. Multiple vesicle liposomes adsorbed on mica and observed within liquids and air show the same average diameter as the ones measured by photon correlation spectroscopy, indicating that their size was unchanged during the drying process. The as prepared liposomes are formed by smaller vesicles that aggregate to give the ~200 nm diameter vesicles. |
full paper (pdf, 320 Kb)